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December 2020

alpha300 apyron nominated for Best New Spectroscopy Product of 2020

WITec’s alpha300 apyron fully automated Raman microscope has been recognized by the SelectScience Scientists’ Choice Awards with a nomination in the category of “Best New Spectroscopy Product of 2020”. We’re very grateful to be in the running for this award, and sincerely appreciate the support that our customers have expressed for our most advanced microscope ever.

The Scientists’ Choice Awards are an industry-wide competition held every year to highlight the new laboratory products that have been most useful to scientists in their work. The researchers themselves directly nominate, review, and vote for the winners.

The alpha300 apyron brings a new level of automation to correlative Raman imaging microscopy by featuring self-optimization and remote operation capabilities. Its software-driven motorized components accelerate experimental setup while reducing user workload and researchers working from home or using environmental enclosures such as glove boxes can acquire data with the click of a mouse.

Vote here for the alpha300 apyron and you could win a $500/£400/450€ Amazon Gift Card:


SCA alpha300 apyron 504


December 2020

WITec supports Albert Einstein Discovery Center with 5,000 Euros

This year, instead of sending Christmas presents to its customers, WITec GmbH is donating 5,000 Euros to the Albert Einstein Discovery Center Association. "As a manufacturer of microscopy systems from Ulm, and through our close connection to physics, it is especially important to us to help make the Albert Einstein Discovery Center a reality," emphasized Dr. Olaf Hollricher, co-founder and head of research and development at WITec. The donation was presented at WITec headquarters in Ulm’s Science Park by Dr. Hollricher and Dr. Joachim Koenen to Dr. Nancy Hecker-Denschlag, Chairwoman of the Albert Einstein Discovery Center Association. Dr. Hollricher added, "I think it’s a good and important effort to create a place that honors this monumental physicist and provides an opportunity to experience his work in the place of his birth."

The Science City of Ulm should live up to its name. Until now, there hasn’t been a scientific museum that illustrates the revolutionary ideas of Albert Einstein, the world's most famous and renowned son of the city of Ulm. The future experience and discovery center will both tell the story of Albert Einstein's life and present his theories and research results. "We need to take advantage of the momentum that now exists and move forward to build this museum soon," explains Dr. Olaf Hollricher. Dr. Nancy Hecker-Denschlag, Chairwoman of the Albert Einstein Discovery Center Association, expressed her happiness with the response, "It's great that so many successful companies from Ulm are participating in the project. So we're all pulling in the same direction, because we're not just doing something for Ulm, we want to create a center of global interest." Those who wish to join the association can already benefit from the lectures and roundtable discussions it hosts and will also soon be able to take part in excursions that cater to the scientific interests of its members.

Albert Einstein Discovery Center home page:

EinsteinSpende01 504

(Left to Right) Dr. Joachim Koenen, Dr. Olaf Hollricher and Dr. Nancy Hecker-Denschlag


December 2020




  キックオフミーティングでは、亀田准教授より、「世界中の海水サンプルの監視や水道水、廃水等の分析などの環境中のマイクロプラスチックを調査するプロジェクトが進行中であり、今後も複数のプロジェクトの計画があります。日本では、これらのプロジェクトでは、20 µmを超えるサイズの粒子に焦点を当てています。さらに小さなマイクロプラスチックでも信頼できる分析方法を利用できるようになることは、我々の研究において大きな前進となるでしょう。また、大気中に浮遊するマイクロプラスチックの実態を把握する方法を確立したいと考えています。私たちが毎日呼吸する空気によって、かなりの量のマイクロプラスチックを私たちの体は取り込んでおり、特に微小な粒子は、健康に非常に有害であると考えられています。 WITecとの協力により、空気中の微小な粒子を識別し、定量化できる分析方法を確立する研究の機会が開かれます。」

 WITec Japanのディレクター ミヒャエル・フェルストは、次のように述べています。「WITecの最新の技術が、千葉工業大学に協力できることは大変光栄です。亀田准教授と彼のチームは、環境化学において優れた研究でよく知られており、マイクロプラスチックを調査するプロジェクトは、特に高く評価されています。 WITecの高性能技術と亀田准教授らのチームの知識と経験を組み合わせることで、私たちを取り巻く環境の現状について新たな洞察を得ることができると確信しています。正確で効率的な分析方法は、よりよい生態系モニタリングと私たちの生活環境や健康の改善につながることを願っています。」


Kameda PR 504

左: 亀田豊准教授 – 千葉工業大、右: ミヒャエル・フェルスト – WITec Japan


December 2020

WITec China moves into a new Beijing office

To keep pace with the rapid growth of the Chinese market for scientific instruments, WITec’s representative office in Beijing has moved to a larger space, now in the Air China Plaza Tower.

Our new location features a dedicated equipment demonstration laboratory where visitors can experience our latest technologies in person, and see the advantages they provide in action. Our Beijing team is also ready to receive visitors and offer consultations regarding the best instrument configuration for researchers’ individual requirements.

If you have any questions about our microscopes, or if you’re interested in having our applications scientists in China perform measurements on one of your samples, please contact us at the address below:

WITec Beijing Representative Office
Unit 1307A, Air China Plaza Tower 1, No. 36 Xiaoyun Road,
Chaoyang District, 100027, Beijing, China

+ 86 (0) 10 6590 0577

Beijing Office 504


November 2020

WITec が Wiley Analytical Science Award 2021 を受賞

ParticleScout recognized by readers as an outstanding innovation

Ulm, Germany
November 24th, 2020

WITec GmbH, innovator of Raman and correlative imaging microscopes, has received a Wiley Analytical Science Award 2021 for its ParticleScout automated particle analysis tool. ParticleScout won 2nd Place in the category: Spectroscopy and Microscopy.

This award celebrates outstanding innovation in equipment used for scientific analysis. A neutral jury of experts at Wiley created a shortlist from the full range of submissions, and then the readers of the print and digital editions of Wiley Analytical Science’s portfolio of journals voted for their favorites. The winners were announced during the Wiley Analytical Science Conference 2020.

“We’re very honored that ParticleScout has been recognized with this award, especially as it was chosen directly by Wiley’s readers,” said Harald Fischer, Marketing Director at WITec. “Being selected as a finalist and then supported by so many individuals I think reflects the strength of our technology, and also a wider awareness that precisely measuring microparticles and microplastics in our environment is an important and timely capability.”

ParticleScout is an advanced particle analysis tool that uses white light and Raman microscopy, a fast, label-free and non-destructive chemical characterization method, to find, classify, identify and quantify microparticles. It streamlines the entire microparticle analysis workflow, increasing the rate at which measurements can be performed and the number of particles that can be evaluated.

ParticleScout’s features include the ability to detect particles less than 1 µm in size, a variety of user-definable Boolean filters for particle categorization, and full integration with a Raman spectral database management software for sample component identification.

WITec ParticleScout product page:

WAS Award 2021 Composite 504 Breit


November 2020




本社増築工事進捗状況の動画 (YouTube):
https://youtu.be/tkVYFiGQoyY   下記ビデオを御覧ください。

プレスリリース (英文):


Drone Video Screenshot 504Breit



October 2020

Virtual Raman Imaging Poster Summit 2020 Successfully Concludes

Online event showcased the latest research and drew international participation

WITec GmbH, the driver of innovation in Raman and correlative microscopy, has completed hosting its first entirely online scientific conference.

The Virtual Raman Imaging Poster Summit 2020 was organized as a substitute for the renowned Confocal Raman Imaging Symposium. WITec wanted to provide a forum for the presentation and discussion of the exciting chemical characterization research that continues to advance while the scientific community is distributed. It was a response to the uncertainty and travel restrictions imposed by the ongoing pandemic, and it was a resounding success.

Over 250 people took part and 55 scientific posters were submitted in four different categories. The range of applications included the analysis of active ingredient and excipient distribution in pharmaceutical tablets, characterization of battery materials, detection of microplastic particles, cancer diagnosis, chemical analyses of organoids and polymer fibers in 3D, bacterial signaling investigation, analysis of microinclusions in arctic ice, extremely high-pressure Raman measurements, strain analyses in semiconductors, and many more.

“We were cautiously optimistic that the community would embrace the online conference format to share their recent work, and then the reaction far exceeded our expectations,” described WITec Marketing Director Harald Fischer. “The diversity, both scientifically and geographically, of the posters submitted really reflected the widespread adoption of Raman imaging.”

Discussions were carried out on the platform’s chat function and participants cast their votes for the Best Poster Award, which was won by Dr. Nathalie Jung (Goethe University, Frankfurt am Main, Germany) for her presentation titled, “Chemically-selective visualisation of organoids and their interaction with hydrogel matrices.”

The Virtual Raman Imaging Poster Summit and the thoroughly international engagement it produced has encouraged WITec to continue developing online event formats while the company looks forward to bringing the Raman imaging community back together in person. The Confocal Raman Imaging Symposium will return for its 17th occasion from September 27th through the 29th, 2021 in Ulm, Germany.

Virtual Raman Imaging Poster Summit 2020 review page:

Confocal Raman Imaging Symposium home page:

WITec PosterAwardWinner2020 news

Dr. Nathalie Jung – Goethe University, Frankfurt am Main, Germany – Winner of the Best Poster Award (© Nathalie Jung)


August 2020

バーチャル ラマンイメージング ポスターサミット2020開催のお知らせ

Online conference offers the Raman community a forum for scientific exchange 

Ulm, Germany
August 11th, 2020

ラマン分光技術の業界リーダーWITec GmbHは、2020年9月28日から10月2日まで、初めてバーチャル ラマンイメージング ポスター サミットを開催します。このオンラインカンファレンスでは、世界中のラマンコミュニティーの皆様が、自宅オフィスやラボなどご都合のよい場所から、日頃の研究を発表し、皆様の情報交換と交流の場をご提供します。セッションのトピックには、ライフサイエンス、バイオ医学および製薬研究、先端材料分析、環境および地球科学、相関イメージングアプリケーションが含まれています。


WITec VirtualPosterSummit2020 web


July 2020

TMDの相関的な高分解能イメージング – ラマン、SHG、PLによるMoS2薄片のイメージング

遷移金属ダイカルコゲナイド(TMD) に代表される2次元材料は、その独特な光学的および電子的特性により、ますます注目されています。それらの用途として、トランジスタ、光検出器、発光ダイオード(LED)、および太陽電池などの製造が考えられます。高品質のデバイスを製造するには、合成プロセスを効率的に評価する必要があります。このため、結晶特性や結晶粒界、層数、欠陥密度、ドーピング、ひずみ場などの特徴を非破壊で観察できるイメージング技術が必要となります。

この新しいアプリケーションノートでは、TMDの調査で利点が確認できるラマン、2次高調波(SHG) 、フォトルミネッセンス (PL) の複合測定での、CVD成長をさせた単層二硫化モリブデン(MoS2)の観察例を紹介します。すべての測定は、ラマンおよびPLイメージング用の532 nmレーザーとSHG励起用のピコ秒パルスレーザー1064 nmの両方を装備したWITec alpha300顕微鏡を用いて同視野の観察を行いました。 

結晶のひずみ場がラマンおよびPLによって可視化され、E2gラマンピークのピークシフト(左上の画像)とPLのピークシフト(左下の画像)の両方が同じ部分で長波長側へシフトしていました。 MoS2薄片の境界の周りのリム効果は、PL像(左下の画像)とA1gラマン像で明瞭に観察されました。(添付のアプリケーションノートを参照してください)

SHG 顕微鏡は、MoS2薄片の結晶方位と対称性に敏感であり、結晶粒界が可視化されます(右上の画像)。さらに偏光依存のSHG観察により、結晶方位を特定し、ひずみ場を画像化することができます。ここでは、励起光の偏光方向を回転させて、励起光と同じ偏光を持つSHG信号成分の強度測定を行いました。一連の偏光を自動化して、 MoS2薄片の3カ所で記録されました(右下の図)。測定された明確なポーラチャートは、異なるひずみのレベルを示しています。


画像とのリファレンスを含めた詳細については、download our 2-page application note on correlative high-resolution imaging of MoS2をダウンロードして下さい。




WITec correlativeImagingOfMoS2 web



July 2020


ラマンイメージングは​​、2D材料のひずみ、ドーピング、欠陥といった品質評価のための非破壊的手法であり、層数の判断も可能です。これらの2つの広領域ラマン像は、CVD成長させたグラフェン薄片の欠陥密度(上)と、ひずみ領域(下)を高い空間分解能(100nm/画素)で可視化します。これらは、532 nm励起レーザーとフォーカストラッキング機能TrueSurfaceを備えた完全自動化ラマン顕微鏡alpha300 apyronにより取得されました。

上のラマン像は、取得したラマンスペクトルのDバンド強度により色分けされています。Dバンド強度は、炭素格子の欠陥密度に依存するため、結晶の欠陥を可視化しています。観察された微細構造の幅は、532 nmのレーザー励起で達成可能な回折限界の横方向分解能とほぼ同じであり、本ラマン顕微鏡が高性能であることを示しています。




WITec Graphene web

CVD成長させたグラフェンの高分解能ラマン像(100 nm/画素)。上:Dバンドのピーク強度のラマン像。結晶欠陥を可視化しています。下:2Dバンドのピークシフトのラマン像。局所的なひずみ/ドーピングによる効果を可視化しています。


July 2020

ParticleScoutは、Wiley社のAnalytical Science Award 2021の候補に選出されました。

私たちは、ParticleScout(自動粒子分析ツール)が、Wiley Analytical Science Award2021のファイナリストに選ばれたことを喜ばしく思います。

厳正かつ公正な審査により、「Spectroscopy & Microscopy」部門で、ParticleScoutを含む6つ製品がノミネートされました。



ParticleScout の詳細は、https://www.witec.de/jp/products/accessories/particlescout/よりご覧いただけます。


Wiley Award 3


July 2020


A paper just published in the Journal of Biophotonics describes how Raman spectoscopy can enable the detection of RNA viruses in human saliva. Dr. Amit Dutt's group at the Tata Memorial Centre, based in Mumbai, obtained raw data with a WITec Raman microscope and carried out statistical analysis to find a set of 65 Raman spectral features that positively identified the presence or absence of viruses in a sample.

The analysis could be performed in less than a minute without adding a reagent to increase the signal. Their signal set was able to achieve 92.5% sensitivity and 88.8% specificity.  

“This conceptual framework to detect RNA viruses in saliva could form the basis for field application of Raman Spectroscopy in managing viral outbreaks, such as the ongoing COVID-19 pandemic,” said the researchers.


RNA Virus Raman

Scientists in the research group of Dr. Amit Dutt, who used Raman microscopy to detect RNA viruses in human saliva samples.


June 2020


Increased capacity required to meet growing demand for Raman imaging microscopes

Ulm, Germany  
June 10th, 2020

WITec GmbH, the technology leader in correlative Raman microscopy, is expanding its headquarters building in Ulm.

The new addition will offer more space for production and quality assurance, laboratories for development and customer demonstrations or sample measurements, larger conference rooms and greater logistical capability. When complete, the new addition will double the amount of space available at WITec’s core location. 

“It was time to expand,” says Joachim Koenen, Co-founder and Managing Director of WITec. “We made advanced Raman imaging much more accessible by simplifying operation through our user-interface and extensive automation. The scientific community and marketplace have reacted very positively to these developments. As more researchers put our instruments in their labs, the word got out, and now we need the increased production capacity.”

WITec’s current headquarters was completed in 2009. Its design reflects the modularity and versatility of the scientific instruments produced within. An open and light-filled interior provides an environment for employees that is conducive to the exchange of ideas. Research and development, sales, applications, production, marketing, administration, technical service and logistics teams all work together hand-in-hand. This greatly contributes to WITec’s vaunted technological agility and preserves its innovative spirit.

As described by Olaf Hollricher, Co-founder and Managing Director of R&D at WITec, “Our headquarters was purpose-built to encourage cross-departmental interaction, from development through shipping, and it’s had a very positive effect on the dynamics and performance of our company. The new expansion will allow us to scale up while adhering to this concept.”

Construction of the new addition will continue through 2020 with an anticipated opening toward the end of 2021.

WTC ANBAU Cropped 504

WITec GmbH’s headquarters building in Ulm, Germany. The highlighted structure shows the addition currently under construction.


June 2020



ライブウェビナーでは、ライブ配信によるオンラインセミナーを開催しています。ライブ中にライブチャット機能を利用して、その場で質疑応答も可能なため、疑問点をすぐに解決できます。  前々から聞きたかったこと、セミナーを受けたからこそ出てくる疑問はチャットでお気軽にご質問ください。






[A-2]20207 1日(水)10:3011:30
[B-2]20207 3日(金)10:3011:30



WITec Webinars


April 2020

WITecが新世代alpha300 apyronを明かす - AutoBeam™ テクノジーを備えた自動ラマンイメージング顕微鏡


Ulm, Germany  
April 28th, 2020

ラマンイメージングと相関顕微鏡のパイオニアであるWITec GmbHは、新しい alpha300 apyron の発表により、自動化と利便性の新しいレベルを確立しました。AutoBeam™ テクノロジーは、WITec の業界をリードする alpha300 seriesの性能を最大限に引き出します。alpha300 apyron の完全に新しい光学、分析、リモート操作機能は、速度・感度・解像度において、これまでで最も大きな進歩を遂げました。

alpha300 apyron は、自己調整と自己校正が可能であり、ユーザーの手入力による実験作業を大幅に削減し、再現性の拡張と潜在的なエラーの原因の最小化を実現します。これを可能にしているのが、WITecの AutoBeam™ 光学機械コンポーネンツで、すべての調査に対して最適な実験を構築・セットアップできる、新しく、幅広い用途のツールキットです。

AutoBeam™ モジュールにより提供される新しい機能として、モーター駆動の偏光子とアナライザーローテーションでの偏光依存測定、オートメーションでの分光計接続およびシグナルの最大化、アイリス絞りの自動調整などがあります。ソフトウェアによる自動化はまた、グローブボックスのような閉鎖された環境や全く別の場所からでも、alpha300 apyron の完全な遠隔操作を可能にします。

WITec の共同創業者・マネージングディレクターの Olaf Hollricher (オラフ・ホリヒャー) は、「 AutoBeam™ ツールキットを備えた alpha300 apyron はラマンイメージングのプロセスの完全自動化への努力の集大成である。自宅からでもリモートコントロールや全ての測定への自己最適化が可能であり、研究者は常に最良の結果を得ることができる。」と述べています。

UV-VISやNIRといった多種多様な励起波長に対応するため、alpha300 apyron 顕微鏡は、3つまでの超高スループットWITec UHTS分光器と関連する範囲の検出器の装備が可能です。ラマンイメージングおよび相関測定は、WITecのSuite FIVEソフトウェアおよび直観的なハンドヘルドコントローラー:EasyLink で定義、実行、保存、評価されます。

WITecは第一世代の apyron よりラマンイメージングの自動化を開始しました。その高度な技術はスパイラル開発の段階で alpha300 の製品群にも導入されました。新たに統合された alpha300シリーズはエントリーレベルの access からフラッグシップの apyron までの連続した範囲の製品群になっています。それらすべては同様に確固たる安定性、ファイバーベースの柔軟性および統合ソフトウェア環境を共有しています。

WITec の共同創業者・マネージングディレクターの Joachim Koenen (ヨハヒム・コーネン)は、「apyron の多くの最先端自動化機能は、過去5年間に渡り、alpha300の顕微鏡シリーズに採用されてきました。 新しい光学機能とハードウェアを開発するにつれ、それらは共通の標準機能として構築されるようになりました。今日では誰もが、自身の特定の研究への要求をそれが進捗するとしても満たせるように、accessapyron あるいはその間の何らかのシステムを構築できます。」と語っています。

alpha300 apyron の利便性により、初心者から上級者までの様々な応用分野のどの研究者にも高度な共焦点ラマンイメージングが可能になります。 材料科学、環境科学、微粒子分析、生命科学、食品科学、地質学、薬学およびその他の多くの分野でご活躍の科学者は、一貫して最適化されたパフォーマンスを提供する自動アライメントルーチンの恩恵を受けることができます。alpha300 apyron は、実験のセットアップとその後の測定ワークフローの両方を高速化します。

新しい alpha300 apyron に関する詳細な情報は、下記リンクでご覧いただけます。



apyron withScreen closed web

第2世代の WITecの alpha300 apyronは、更なる自動化とより充実した光学機能を提供します


April 2020


毎年行われるWITecペーパーアワード(WITec Paper Award)は、WITec顕微鏡を使用し取得した特徴的な研究データについて、特に優秀と認められる査読付き 論文3件を表彰しています。本年度は、過去最高記録113件のご応募がありました。ほんの一例を挙げますと、半導体研究、電気化学、癌研究、地質学、マイクロプラスチックの研究など、種々の分野で多様なニーズに対しラマンイメージングが有用であることを確認しています WITecは、ご応募くださった研究者の皆様に心より感謝申し上げます。本年度のアワードは、電気化学、生物医学、高分子科学の分野において優れたな研究内容と手法が評価された日本、ポーランド、オーストリアの其々の研究者に授与されました。

  • GOLD: Ankur Baliyan and Hideto Imai (2019) Machine Learning based Analytical Framework for Automatic Hyperspectral Raman Analysis of Lithium-ion Battery Electrodes. Scientific Reports 9: 18241. doi.org/10.1038/s41598-019-54770-2
  • SILVER: Ewelina Wiercigroch, Elzbieta Stepula, Lukasz Mateuszuk, Yuying Zhang, Malgorzata Baranska, Stefan Chlopicki, Sebastian Schlücker and Kamilla Malek (2019) ImmunoSERS Microscopy for the Detection of Smooth Muscle Cells in Atherosclerotic Plaques. Biosensors and Bioelectronics 133: 79-85. doi.org/10.1016/j.bios.2019.02.068
  • BRONZE: Ruth Schmidt, Harald Fitzek, Manfred Nachtnebel, Claudia Mayrhofer, Hartmuth Schröttner and Armin Zankel (2019) The Combination of Electron Microscopy, Raman Microscopy and Energy Dispersive X-Ray Spectroscopy for the Investigation of Polymeric Materials. Macromolecular Symposia 384: 1800237. doi.org/10.1002/masy.201800237

 For a list of all previous Paper Award winners, please visit www.witec.de/paper-award.

The Paper Award GOLD: Automated quality control of lithium-ion batteries

Lithium-ion batteries (LIBs) provide the power for most electric devices that we use every day, such as cell phones, tablets and laptops. Their development was honored with the Nobel Prize in Chemistry last year. Automated real-time quality control of LIB materials is necessary for industrial research and production. Ankur Baliyan and Hideto Imai from Nissan Arc. (Yokosuka, Japan) win the Gold Paper Award 2020 for their machine learning-based approach to analyzing Raman data of LIBs. Raman images of LIB cathodes can visualize the spatial distribution of the active cathode material (lithium nickel manganese cobalt oxide, abbreviated as LiMO2) and the surrounding carbon matrix. In order to automate and accelerate the process of identifying the spectral signatures in Raman datasets, the authors developed a machine learning-based analytical framework. It starts by automatically pre-processing the Raman data to remove the baseline and cosmic rays. Next, algorithms determine the number of components, extract the corresponding spectral signatures, and identify them. The spectra are finally used to train a neural network, which can then automatically analyze Raman data from the same or a different LIB sample. The authors demonstrated that data analysis by the trained neural network yielded results consistent with results from an experienced user. However, the algorithm found two minor signatures in addition to the main components of carbon and LiMO2 that corresponded to a residual background signal and one of the main components exhibiting increased fluorescence signals. The presented approach requires very little user input and is thus suitable for real-time quality control using Raman data from lithium-ion batteries and other applications.

The Paper Award SILVER: Characterizing atherosclerotic plaques with iSERS microscopy

“Atherosclerosis is one of the major causes of death worldwide. Understanding the mechanism of its formation still remains a great challenge in medicine. Powerful techniques for monitoring the composition and stability of atherosclerotic plaques are thus needed,” says Ewelina Wiercigroch from Jagiellonian University (Krakow, Poland), winner of the Silver Paper Award 2020. Atherosclerotic plaques form at arterial walls and narrow the blood vessels. Monitoring the stability of the plaques is of clinical relevance because their rupture can result in a stroke or heart attack. As smooth muscle cells (SMCs) play a key role in stabilizing the plaques, their presence can serve as a marker for plaque stability. Ewelina Wiercigroch, Elzbieta Stepula, Lukasz Mateuszuk, Yuying Zhang, Malgorzata Baranska, Stefan Chlopicki, Sebastian Schlücker and Kamilla Malek from Jagiellonian University and the University of Duisburg-Essen (Germany) demonstrated the suitability of immuno surface-enhanced Raman scattering (iSERS) microscopy for staining SMCs in atherosclerotic plaques. SERS labels were conjugated either with a primary antibody directed against α-actin of SMCs (direct iSERS) or with an appropriate secondary antibody (indirect iSERS). The iSERS images of mouse artery sections visualized regions containing SMCs and cluster analysis allowed the quantification of the percentage of SMCs located in the plaques. Results from iSERS staining agreed qualitatively and quantitatively with those from immunofluorescence (IF) staining. IF is the current gold standard in visualizing atherosclerotic constituents, but iSERS offers some advantages, such as higher photostability. The study thus establishes iSERS as a promising technique for visualizing and quantifying SMCs in atherosclerotic plaques.

The Paper Award BRONZE: Correlative Raman imaging of polymeric materials

Ruth Schmidt from Graz University of Technology (Graz, Austria) receives the Bronze Paper Award 2020, together with her colleagues Harald Fitzek, Manfred Nachtnebel, Claudia Mayrhofer, Hartmuth Schröttner and Armin Zankel. The group demonstrated the potential of correlative Raman Imaging and Scanning Electron (RISE) microscopy and Energy Dispersive X-Ray Spectroscopy (EDXS) for investigating polymers. Polymeric materials are popular in many applications due to their wide variety of useful properties, such as high elasticity or toughness. For characterizing their properties, the advantages of three imaging techniques were combined. Scanning Electron Microscopy (SEM) acquired high-resolution structural information, while Raman imaging revealed the chemical composition and was complemented by elemental information from EDXS. The publication provides a detailed methodology chapter which describes different sample preparation approaches and imaging modes. For example, it explains strategies for SEM imaging without coating the sample, which would hinder subsequent Raman imaging. Three polymer specimens were investigated with RISE and EDXS, yielding complementary information from the same sample region. Coarse and fine structures of the samples were correlated with chemical properties and the layer structure of packaging materials was visualized. Particulate additives in a polymer matrix were identified and their size distribution was investigated. The authors stressed that combined SEM, Raman imaging and EDXS offers great possibilities for analyzing polymeric materials.

2021年度 WITecペーパーアワード  応募受付中



PaperAward2020 CombinedPictures

The winners of the WITec Paper Award 2020. Top: Gold winners Ankur Baliyan (middle) and Hideto Imai (right) together with WITec K.K. representative director Michael Verst (left). Middle: Silver winner Ewelina Wiercigroch (middle) and her co-authors (clockwise, beginning top left): Elzbieta Stepula, Yuying Zhang, Lukasz Mateuszuk, Kamilla Malek, Sebastian Schlücker, Malgorzata Baranska and Stefan Chlopicki. (© E. Wiercigroch) Bottom: Bronze winner Ruth Schmidt (middle) and her co-authors from left to right: Armin Zankel, Claudia Mayrhofer and Hartmuth Schröttner (top row); Manfred Nachtnebel and Harald Fitzek (bottom row). (© FELMI-ZFE)


March 2020

Application Note on Raman Imaging of Semiconducting Materials

WITec has released a new Application Note that features measurements of semiconducting materials using 2D and 3D Raman imaging in combination with other techniques such as atomic force microscopy (AFM), scanning electron microscopy (SEM) and second or third harmonic generation (SHG, THG) microscopy. See how correlative techniques can characterize crystallinity, topography, stress fields and other properties on materials such as silicon, gallium nitride and molybdenum disulfide.

WITec AppNote Semiconductors Cover


February 2020

WITec Japan Opens New Office in Yokohama





WITec 株式会社 
〒231-0032 神奈川県横浜市中区不老町1-1-5
横浜東芝ビル 8F

JR関内駅 南口徒歩2分

Office Lab 500 285


February 2020

Physics World Interview with WITec Co-Founder

Physics World Magazine conducted a wide-ranging interview with WITec Co-founder and Director of Research and Development, Olaf Hollricher, in the days leading up to the MRS Fall Meeting and Exhibit at the end of last year.

The article, Confocal Raman microscopy: correlate and accumulate, highlights the versatility of the technique and the modular architecture of WITec’s microscopes. It describes how Raman imaging can be integrated with other methods within one instrument to provide a more comprehensive picture of a sample’s chemical composition and distribution. The potential of this approach, known as correlative microscopy, and the growing demand for it in the marketplace are examined. Dr. Hollricher also discusses the seemingly contradictory challenges that have been overcome in pursuit of both capability and accessibility. Two of WITec’s standout innovations, TrueSurface topographic Raman imaging, and the ParticleScout microparticle analysis tool are detailed as well.

Download the .pdf of the interview or read it on the Physics World website through the link below.


Physics World 500 285


January 2020

ParticleScout Nominated for SelectScience Scientists' Choice Award

WITec's ParticleScout has been nominated for a SelectScience Scientists' Choice Award in the category of Best New Spectroscopy Product. We're very excited to be in the competition and thankful to our customers around the world for their enthusiasm.

The Scientists' Choice Awards are presented annually to recognize the laboratory products introduced in the preceding year that helped researchers the most in the course of their work. Scientists themselves directly nominate, review, and vote for the winners.

WITec's ParticleScout is an automated microparticle anaylsis tool for the alpha300 line of confocal Raman microscopes that can find, classify and identify microplastics and other particles with industry-leading speed and precision. If you'd like to voice your support for this revolutionary and timely technology, please vote through the link below. All participants are entered into a drawing for the chance to win a $500/£400/450€ Amazon Gift Card. Voting ends February 21st.

Vote here: https://www.selectscience.net/editorial-articles/vote-for-best-new-general-lab-and-analytical-science-products-in-the-scientists-choice-awards/?artID=50564

ParticleScout Scientists Choice Award 504


January 2020

WITec Consolidates Sales, Applications and Technical Support for French Market

WITec GmbH, industry-leading manufacturer of 3D confocal Raman imaging and correlative microscopy systems, has updated its organizational structure in France to streamline communication and better leverage in-house technical expertise.

Dr. Maxime Tchaya, a longtime member of the WITec team, will manage the French market directly. His responsibilities include all sales activities and the coordination of technical support, equipment demonstrations and sample measurements.

Dr. Tchaya is native French speaker who began with WITec as an applications scientist before bringing his thorough, practical knowledge of WITec microscopes to the sales department. This experience will enable him to precisely address the requirements of the local client base while providing them with a direct conduit to WITec’s research and development group.

WITec renforce son service commercial et technique sur le marché français

WITec GmbH, leader de la microscopie confocale Raman 3D et fabriquant de plateformes de microscopie corrélative, renforce son organisation en France.

Dr. Maxime Tchaya, membre de longue date de l'équipe WITec, prend la responsabilité de la commercialisation et du support des solutions WITec en France. 

Sa longue expérience au sein de l’équipe d’application, et son excellente connaissance du marché français, sont autant d’atouts qui lui permettront de répondre avec précision et efficacité aux besoins de la clientèle, tout en la rapprochant davantage de l’équipe R&D pour les demandes spécifiques.


Dr. Maxime Tchaya
Area Manager France - Canada - Poland
Lise-Meitner-Str. 6
89081 Ulm, Germany
Tel: +49 (0) 731 140700






Dr. Maxime Tchaya. New Area Manager France, Canada and Poland